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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | DNA-dependent protein kinase catalytic subunit | ||
| Ligand | BDBM648232 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DNAPK Enzyme Potency Assay (DNA-PK Enz) | ||
| IC50 | <0.100±n/a nM | ||
| Citation |  Finlay, MR; Goldberg, FW; Howard, MR; Ting, AK Purinone compounds and their use in treating cancer US Patent US11884671 Publication Date 1/30/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| DNA-dependent protein kinase catalytic subunit | |||
| Name: | DNA-dependent protein kinase catalytic subunit | ||
| Synonyms: | DNA-PK catalytic subunit | DNA-PKcs | DNA-dependent protein kinase (DNA-PK) | DNA-dependent protein kinase (DNPK) | DNA-dependent protein kinase catalytic subunit (DNA-PK) | DNPK1 | HYRC | HYRC1 | PRKDC | PRKDC_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 469114.78 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P78527 | ||
| Residue: | 4128 | ||
| Sequence: |
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| BDBM648232 | |||
| n/a | |||
| Name | BDBM648232 | ||
| Synonyms: | US11884671, Example 9 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H26N6O3 | ||
| Mol. Mass. | 434.4909 | ||
| SMILES | COc1ccnc2cc(C)c(Nc3ncc4n(C)c(=O)n([C@H]5CC[C@H](O)CC5)c4n3)cc12 |r,wU:24.24,wD:21.20,(2.01,2.74,;2.01,1.2,;3.34,.43,;4.68,1.2,;6.01,.43,;6.01,-1.11,;4.68,-1.88,;4.68,-3.42,;3.34,-4.19,;3.34,-5.73,;2.01,-3.42,;.68,-4.19,;-.66,-3.42,;-1.99,-4.19,;-3.33,-3.42,;-3.33,-1.88,;-4.47,-.85,;-6.01,-.85,;-3.84,.56,;-4.61,1.89,;-2.31,.4,;-1.54,1.73,;-0,1.73,;.77,3.06,;-0,4.4,;.77,5.73,;-1.54,4.4,;-2.31,3.06,;-1.99,-1.11,;-.66,-1.88,;2.01,-1.88,;3.34,-1.11,)| | ||
| Structure | 
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