| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM652621 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Determination of Related Protease Inhibition |
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| IC50 | 2.00±n/a nM |
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| Citation |  CHILDS, ML; DAVIE, RL; EDWARDS, HJ; EVANS, DM; GREVES, WJ; HODGSON, ST; MAZZACANI, A; NORTH, CL; OBARA, AS; ROE, MB; ROOKER, DP; STOCKS, MJ; BIRCH, LM; PICHOWICZ, M; PITTAWAY, R; SMITH, AJ; THROUP, AE; WRIGGLESWORTH, JW; YANG, X; CLARK, DE ENZYME INHIBITORS US Patent US20240059691 Publication Date 2/22/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM652621 |
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| n/a |
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| Name | BDBM652621 |
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| Synonyms: | 5-N-[(4-{[(1-ethylpiperidin-4-yl)oxy]methyl}-2-fluorophenyl)methyl]isoquinoline-1,5- diamine | US20240059691, Example 2201 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29FN4O |
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| Mol. Mass. | 408.5117 |
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| SMILES | CCN1CCC(CC1)OCc1ccc(CNc2cccc3c(N)nccc23)c(F)c1 |
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| Structure | 
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