| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM652658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Determination of Related Protease Inhibition |
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| IC50 | 3.00±n/a nM |
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| Citation |  CHILDS, ML; DAVIE, RL; EDWARDS, HJ; EVANS, DM; GREVES, WJ; HODGSON, ST; MAZZACANI, A; NORTH, CL; OBARA, AS; ROE, MB; ROOKER, DP; STOCKS, MJ; BIRCH, LM; PICHOWICZ, M; PITTAWAY, R; SMITH, AJ; THROUP, AE; WRIGGLESWORTH, JW; YANG, X; CLARK, DE ENZYME INHIBITORS US Patent US20240059691 Publication Date 2/22/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM652658 |
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| n/a |
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| Name | BDBM652658 |
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| Synonyms: | 4-N-[[2-[(1-methyl-4-piperidyl)methoxy]-4-pyridyl]methyl]-1,7-naphthyridine-4,8- diamine | US20240059691, Example 4272 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26N6O |
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| Mol. Mass. | 378.4707 |
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| SMILES | CN1CCC(COc2cc(CNc3ccnc4c(N)nccc34)ccn2)CC1 |
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| Structure | 
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