| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Plasma kallikrein |
|---|
| Ligand | BDBM652682 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Determination of Related Protease Inhibition |
|---|
| IC50 | 1.000±n/a nM |
|---|
| Citation |  CHILDS, ML; DAVIE, RL; EDWARDS, HJ; EVANS, DM; GREVES, WJ; HODGSON, ST; MAZZACANI, A; NORTH, CL; OBARA, AS; ROE, MB; ROOKER, DP; STOCKS, MJ; BIRCH, LM; PICHOWICZ, M; PITTAWAY, R; SMITH, AJ; THROUP, AE; WRIGGLESWORTH, JW; YANG, X; CLARK, DE ENZYME INHIBITORS US Patent US20240059691 Publication Date 2/22/2024 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Plasma kallikrein |
|---|
| Name: | Plasma kallikrein |
|---|
| Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 71391.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03952 |
|---|
| Residue: | 638 |
|---|
| Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
|
|
|
|---|
| BDBM652682 |
|---|
| n/a |
|---|
| Name | BDBM652682 |
|---|
| Synonyms: | 5-N-({2-[(1-isopropylpiperidin-4-yl)methoxy]pyridin-4-yl}methyl)isoquinoline-1,5- diamine | US20240059691, Example 4299 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H31N5O |
|---|
| Mol. Mass. | 405.5358 |
|---|
| SMILES | CC(C)N1CCC(COc2cc(CNc3cccc4c(N)nccc34)ccn2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
