| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM627157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DGAT2 Enzymatic Activity Assay |
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| IC50 | 17.0±n/a nM |
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| Citation |  Lim, Y; Bao, J; Cruz, FA; Ding, F; Hugelshofer, CL; Mak, VW; Roane, JP; Sanzone, JR; Shockley, SE; Yen, R NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS US Patent US20240059700 Publication Date 2/22/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM627157 |
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| n/a |
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| Name | BDBM627157 |
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| Synonyms: | 3-(3-(difluoromethoxy)phenyl)-1- (5-fluoropyrimidin-2-yl)-N-(3- methyl-1,1-dioxidothietan-3-yl)- 1H-pyrazolo[4,3-b]pyridine-6- carboxamide | US11787810, Example 4 | US20240059700, Example 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17F3N6O4S |
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| Mol. Mass. | 518.468 |
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| SMILES | CC1(CS(=O)(=O)C1)NC(=O)c1cnc2c(nn(-c3ncc(F)cn3)c2c1)-c1cccc(OC(F)F)c1 |
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| Structure | 
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