Ki Summary

Reaction Details

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Target

Toll-like receptor 7

Ligand

BDBM655242

Substrate/Competitor

n/a

Meas. Tech.

TLR7/8/9 Inhibition Reporter Assays

IC50

0.220±n/a nM

Citation

Dyckman, AJ; Dodd, DS; Kumar, SR; Barre, DB; Duraisamy, SK 6-azaindole compounds US Patent US11912703 Publication Date 2/27/2024

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 7

Name:

Toll-like receptor 7

Synonyms:

ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)

Type:

Enzyme

Mol. Mass.:

120945.35

Organism:

Homo sapiens (Human)

Description:

Q9NYK1

Residue:

1049

Sequence:

MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV

BDBM655242

n/a

Name

BDBM655242

Synonyms:

US11912703, Example 105 | US11912703, Example 192

Type

Small organic molecule

Emp. Form.

C27H33FN6O2

Mol. Mass.

492.5883

SMILES

COc1cc(cn2ncnc12)-c1[nH]c2cnc(C3CCC(CC3)NC3(C)COC3)c(F)c2c1C(C)C |(9.81,1.62,;8.27,1.62,;7.5,.29,;5.96,.29,;5.19,-1.04,;5.96,-2.38,;7.5,-2.38,;8.53,-3.52,;9.94,-2.9,;9.78,-1.36,;8.27,-1.04,;3.65,-1.04,;2.75,-2.29,;1.28,-1.81,;-.05,-2.58,;-1.39,-1.81,;-1.39,-.27,;-2.72,.5,;-2.72,2.04,;-4.05,2.81,;-5.39,2.04,;-5.39,.5,;-4.05,-.27,;-6.72,2.81,;-8.05,2.04,;-8.45,3.52,;-9.54,2.43,;-9.94,.95,;-8.45,.55,;-.05,.5,;-.05,2.04,;1.28,-.27,;2.75,.2,;3.15,1.69,;2.06,2.78,;4.63,2.09,)|

Structure