Ki Summary

Reaction Details

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Target

Toll-like receptor 8

Ligand

BDBM655300

Substrate/Competitor

n/a

Meas. Tech.

TLR7/8/9 Inhibition Reporter Assays

IC50

0.270±n/a nM

Citation

Dyckman, AJ; Dodd, DS; Kumar, SR; Barre, DB; Duraisamy, SK 6-azaindole compounds US Patent US11912703 Publication Date 2/27/2024

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 8

Name:

Toll-like receptor 8

Synonyms:

CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8

Type:

Enzyme

Mol. Mass.:

119828.77

Organism:

Homo sapiens (Human)

Description:

Q9NR97

Residue:

1041

Sequence:

MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY

BDBM655300

n/a

Name

BDBM655300

Synonyms:

US11912703, Example 134 | US11912703, Example 232

Type

Small organic molecule

Emp. Form.

C29H37FN6O

Mol. Mass.

504.6421

SMILES

CC(C)c1c([nH]c2cnc(C3CCC(CC3)NC3CCOCC3)c(F)c12)-c1cn2ncnc2c(C)c1C |(2.45,3.23,;3.54,2.14,;5.02,2.54,;3.14,.65,;4.04,-.59,;3.14,-1.84,;1.67,-1.36,;.34,-2.13,;-.99,-1.36,;-.99,.18,;-2.33,.95,;-2.33,2.49,;-3.66,3.26,;-5,2.49,;-5,.95,;-3.66,.18,;-6.33,3.26,;-7.66,2.49,;-9,3.26,;-10.33,2.49,;-10.33,.95,;-9,.18,;-7.66,.95,;.34,.95,;.34,2.49,;1.67,.18,;5.58,-.59,;6.35,.74,;7.89,.74,;8.92,1.89,;10.33,1.26,;10.17,-.27,;8.66,-.59,;7.89,-1.93,;8.66,-3.26,;6.35,-1.93,;5.58,-3.26,)|

Structure