Reaction Details | |||
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Target | Tyrosine-protein kinase JAK2 | ||
Ligand | US20240092758, Example 121 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical JAK Kinase Assays | ||
Ki | <0.1±n/a nM | ||
Citation | MCKINNELL, RM; LAM, TM; SMITH, C; GERKEN, P; ALLEGRETTI, P; DOLGONOS, GE; OWENS, C IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS US Patent US20240092758 Publication Date 3/21/2024 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK2 | |||
Name: | Tyrosine-protein kinase JAK2 | ||
Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
Type: | Protein | ||
Mol. Mass.: | 130684.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60674 | ||
Residue: | 1132 | ||
Sequence: |
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US20240092758, Example 121 | |||
n/a | |||
Name | US20240092758, Example 121 | ||
Synonyms: | n/a | ||
Type | Small organic molecule | ||
Emp. Form. | C29H32FN5O2 | ||
Mol. Mass. | 501.5951 | ||
SMILES | CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1F)-c1nc(c[nH]1)C1=CCN(CC1)C1CCC(O)CC1 |t:28,(-3.46,.91,;-4.79,1.68,;-6.13,.91,;-7.46,1.68,;-8.8,.91,;-10.13,1.68,;-8.8,-.63,;-7.46,-1.4,;-6.13,-.63,;-4.79,-1.4,;-3.46,-.63,;-2.13,-1.4,;-2.13,-2.94,;-.98,-3.97,;-1.61,-5.38,;-3.14,-5.22,;-3.46,-3.71,;-4.79,-2.94,;-6.13,-3.71,;.52,-3.65,;1.15,-2.25,;2.68,-2.41,;3,-3.91,;1.67,-4.68,;3.71,-1.26,;5.22,-1.58,;6.25,-.44,;5.77,1.03,;4.27,1.35,;3.24,.2,;6.86,2.11,;8.35,1.72,;9.44,2.8,;9.04,4.29,;10.13,5.38,;7.55,4.69,;6.46,3.6,)| | ||
Structure |