Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK1

Ligand

US20240092758, Example 128

Substrate/Competitor

n/a

Meas. Tech.

Biochemical JAK Kinase Assays

<0.1±n/a nM

Citation

MCKINNELL, RM; LAM, TM; SMITH, C; GERKEN, P; ALLEGRETTI, P; DOLGONOS, GE; OWENS, C IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS US Patent US20240092758 Publication Date 3/21/2024

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK1

Name:

Tyrosine-protein kinase JAK1

Synonyms:

Type:

Protein

Mol. Mass.:

133293.73

Organism:

Homo sapiens (Human)

Description:

P23458

Residue:

1154

Sequence:

MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK

US20240092758, Example 128

n/a

Name

US20240092758, Example 128

Synonyms:

n/a

Type

Small organic molecule

Emp. Form.

C28H31N5O2

Mol. Mass.

469.578

SMILES

CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc(c[nH]1)C1=CCN(C1)[C@H]1CC[C@H](O)CC1 |r,wU:28.32,wD:31.36,t:27,(-1.66,.04,;-3,.81,;-4.33,.04,;-5.66,.81,;-7,.04,;-8.33,.81,;-7,-1.5,;-5.66,-2.27,;-4.33,-1.5,;-3,-2.27,;-1.66,-1.5,;-.33,-2.27,;-.33,-3.81,;.81,-4.84,;.19,-6.25,;-1.34,-6.09,;-1.66,-4.58,;-3,-3.81,;2.32,-4.52,;2.95,-3.12,;4.48,-3.28,;4.8,-4.78,;3.47,-5.55,;5.51,-2.13,;7.04,-2.29,;7.67,-.89,;6.52,.14,;5.19,-.63,;6.68,1.68,;5.47,2.63,;5.69,4.15,;7.12,4.72,;7.34,6.25,;8.33,3.77,;8.11,2.25,)|

Structure