| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [64-515] |
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| Ligand | US20240101536, Example 153 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ABL1 Biochemical Kinase Assay |
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| IC50 | 0.280±n/a nM |
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| Citation |  ROMERO, FA; KIRSCHBERG, TA; HALCOMB, R; XU, Y COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS US Patent US20240101536 Publication Date 3/28/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ABL1 [64-515] |
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| Name: | Tyrosine-protein kinase ABL1 [64-515] |
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| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51539.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 64-515 |
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| Residue: | 452 |
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| Sequence: | NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
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| US20240101536, Example 153 |
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| n/a |
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| Name | BDBM477807 |
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| Synonyms: | US10889571, Example 153 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H18ClF2N5O3 |
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| Mol. Mass. | 509.892 |
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| SMILES | C[C@@H]1COCc2nc3cc(cc(-c4cncc(c4)C#N)c3n12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |r| |
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| Structure | 
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