Ki Summary

Reaction Details

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Target

Fatty acid-binding protein 5

Ligand

BDBM312347

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved-Fluorescence Energy Transfer (TR-FRET) Assay

IC50

10.00±n/a nM

Citation

Buettelmann, B; Ceccarelli, SM; Kuehne, H; Kuhn, B; Neidhart, W; Obst Sander, U; Richter, H Bicyclic thiophenylamide compounds US Patent US9604977 Publication Date 3/28/2017

More Info.:

Get all data from this article, Assay Method

Fatty acid-binding protein 5

Name:

Fatty acid-binding protein 5

Synonyms:

FABP5 | FABP5_HUMAN | Fatty acid binding protein epidermal | Fatty acid-binding protein 5 (FABP5)

Type:

Enzyme

Mol. Mass.:

15164.79

Organism:

Homo sapiens (Human)

Description:

Q01469

Residue:

135

Sequence:

MATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTL
KTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVEC
VMNNVTCTRIYEKVE

BDBM312347

n/a

Name

BDBM312347

Synonyms:

3-[3-(3-Cyclopropyl-[1,2,4]oxadiazol-5-yl)-6-methyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-ylcarbamoyl]-bicyclo[2.2.2]oct-2-ene-2-carboxylic acid | US9604977, Example 93

Type

Small organic molecule

Emp. Form.

C24H27N3O4S

Mol. Mass.

453.554

SMILES

CC1CCc2c(C1)sc(NC(=O)C1=C(C3CCC1CC3)C(O)=O)c2-c1nc(no1)C1CC1 |t:13,(-6.65,-2.22,;-5.32,-1.45,;-5.32,.09,;-3.98,.86,;-2.65,.09,;-2.65,-1.45,;-3.98,-2.22,;-1.18,-1.93,;-.28,-.68,;1.26,-.68,;2.03,-2.02,;1.26,-3.35,;3.57,-2.02,;4.34,-3.35,;5.88,-3.35,;6.65,-2.02,;5.88,-.68,;4.34,-.68,;5.67,-1.45,;4.55,-2.58,;3.57,-4.68,;2.03,-4.68,;4.34,-6.02,;-1.18,.56,;-.41,1.9,;1.05,2.37,;1.05,3.91,;-.41,4.39,;-1.32,3.14,;2.38,4.68,;3.92,4.68,;3.15,6.02,)|

Structure