Reaction Details |
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Target | BDNF/NT-3 growth factors receptor |
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Ligand | BDBM164936 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro TrkB Activity |
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IC50 | 13.0±n/a nM |
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Citation | Kane, Jr., JL; Matthews, G; Metz, M; Kothe, M; Liu, J; Scholte, A Tropomyosin-related kinase (Trk) inhibitors US Patent US10166239 Publication Date 1/1/2019 |
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More Info.: | Get all data from this article, Assay Method |
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BDNF/NT-3 growth factors receptor |
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Name: | BDNF/NT-3 growth factors receptor |
Synonyms: | GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B) |
Type: | Enzyme |
Mol. Mass.: | 91996.87 |
Organism: | Homo sapiens (Human) |
Description: | Q16620 |
Residue: | 822 |
Sequence: | MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL
KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI
VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI
AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM
PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ
EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
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BDBM164936 |
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n/a |
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Name | BDBM164936 |
Synonyms: | US10166239, Ex. 3-37-4 | US11406644, Example 3-37-4 | US9067914, Ex. 3-37-4 |
Type | Small organic molecule |
Emp. Form. | C27H29N7O3 |
Mol. Mass. | 499.5643 |
SMILES | COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3c(C)nn(C)c3C)cc2OC)cn1 |
Structure |
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