| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
|---|
| Ligand | BDBM143787 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radioligand Binding Assay |
|---|
| Ki | 3.00±n/a nM |
|---|
| Citation |  Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US9611277 Publication Date 4/4/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Orexin/Hypocretin receptor type 1 |
|---|
| Name: | Orexin/Hypocretin receptor type 1 |
|---|
| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46817.55 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P56718 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
|
|
|
|---|
| BDBM143787 |
|---|
| n/a |
|---|
| Name | BDBM143787 |
|---|
| Synonyms: | US10183953, Example 48 | US8969352, 48 | US9611277, Example 48 | US9845333, 48 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H18BrFN4O2 |
|---|
| Mol. Mass. | 469.306 |
|---|
| SMILES | Fc1cccc(C(=O)N2CC3CC(Oc4ccc(Br)cn4)C2C3)c1-c1ncccn1 |TLB:13:12:8.9:22,6:8:12.11:22| |
|---|
| Structure | 
|
|---|
Search and Browse
