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TargetOrexin/Hypocretin receptor type 1
LigandBDBM315088
Substrate/Competitorn/a
Meas. Tech.Radioligand Binding Assay
Ki 4.00±n/a nM
Citation Gelin, CFLebold, TPShireman, BTZiff, JM Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US9611277 Publication Date 4/4/2017
More Info.:Get all data from this article,  Assay Method
 
Orexin/Hypocretin receptor type 1
Name:Orexin/Hypocretin receptor type 1
Synonyms:Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:Protein
Mol. Mass.:46817.55
Organism:Rattus norvegicus (Rat)
Description:P56718
Residue:416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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  Blast E-value cutoff:
BDBM315088
n/a
NameBDBM315088
Synonyms:((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone | US10183953, Example 269 | US9611277, Example 269
TypeSmall organic molecule
Emp. Form.C23H20BrFN4O2
Mol. Mass.483.333
SMILESFc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1 |TLB:16:14:11.12:9.8,THB:6:8:14.15:11.12|
Structure
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