| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM614763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Calcium Flux Assays (hB1 IC50 free) |
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| IC50 | 18.0±n/a nM |
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| Citation |  BAEURLE, S; DAVENPORT, A; STIMSON, C; NAGEL, J; SCHMIDT, N; ROTGERI, A; GROETICKE, I; RAUSCH, A; KLAR, J; DYRKS, T CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR US Patent US20230271931 Publication Date 8/31/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM614763 |
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| n/a |
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| Name | BDBM614763 |
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| Synonyms: | 2-(1- Cyclopentyl-1H- pyrazol-4-yl)-5- [({1-[2-fluoro-4- (trifluoromethyl) phenyl]cyclo- propyl}carbonyl) amino]benzoic acid | US20230271931, Example 121 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23F4N3O3 |
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| Mol. Mass. | 501.4727 |
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| SMILES | OC(=O)c1cc(NC(=O)C2(CC2)c2ccc(cc2F)C(F)(F)F)ccc1-c1cnn(c1)C1CCCC1 |
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| Structure | 
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