| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
|---|
| Ligand | BDBM318382 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Z′-LYTE Kinase Assay |
|---|
| IC50 | <50±n/a nM |
|---|
| Citation |  Li, L; Wu, T; Feng, J; Ren, P; Liu, Y Inhibitors of ERK and methods of use US Patent US9624228 Publication Date 4/18/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 1 |
|---|
| Name: | Mitogen-activated protein kinase 1 |
|---|
| Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
|---|
| Type: | Ser/Thr Protein Kinase |
|---|
| Mol. Mass.: | 41392.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P28482 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
|
|
|
|---|
| BDBM318382 |
|---|
| n/a |
|---|
| Name | BDBM318382 |
|---|
| Synonyms: | US10301317, Example 340 | US9624228, Example 340 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H22F3N7O |
|---|
| Mol. Mass. | 493.4837 |
|---|
| SMILES | FC(F)(F)CN1C[C@H]([C@@H](C1)c1ccccc1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnnc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
