Reaction Details |
| Report a problem with these data |
Target | Phosphatidylinositol 3-kinase regulatory subunit beta |
---|
Ligand | BDBM320570 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In Vitro Enzyme PI3K Assay |
---|
IC50 | 1154±n/a nM |
---|
Citation | Samby, KK; Surase, YB; Amale, SR; Gorla, SK; Patel, P; Verma, AK 6-morpholinyl-2-pyrazolyl-9H-purine derivatives and their use as PI3K inhibitors US Patent US10174035 Publication Date 1/8/2019 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Phosphatidylinositol 3-kinase regulatory subunit beta |
---|
Name: | Phosphatidylinositol 3-kinase regulatory subunit beta |
Synonyms: | P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta |
Type: | Enzyme Subunit |
Mol. Mass.: | 81542.75 |
Organism: | Homo sapiens (Human) |
Description: | O00459 |
Residue: | 728 |
Sequence: | MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALG
PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
PGPPPAAR
|
|
|
BDBM320570 |
---|
n/a |
---|
Name | BDBM320570 |
Synonyms: | US10174035, Compound 113 | {4-[cis-2,6-Dimethylmorpholin-4-yl]piperidin-1-yl}[5-(1,3-dimethyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl]methanone |
Type | Small organic molecule |
Emp. Form. | C27H38N8O3 |
Mol. Mass. | 522.6424 |
SMILES | C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1 |
Structure |
|