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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Chromatin remodeling regulator CECR2 [424-538] | ||
| Ligand | BDBM321447 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | IC50 Measurements for Inhibitors Using TAF1-BD2 TR-FRET Binding Assay | ||
| IC50 | 5200±n/a nM | ||
| Citation |  Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent US10183009 Publication Date 1/22/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Chromatin remodeling regulator CECR2 [424-538] | |||
| Name: | Chromatin remodeling regulator CECR2 [424-538] | ||
| Synonyms: | CECR2 | CECR2 (aa 424-538) | CECR2_HUMAN | Cat eye syndrome critical region protein 2 [424-538] | KIAA1740 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 13747.10 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9BXF3[424-538] | ||
| Residue: | 115 | ||
| Sequence: |
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| BDBM321447 | |||
| n/a | |||
| Name | BDBM321447 | ||
| Synonyms: | N,N-dimethyl-3-[6-(3-methylbut-2-enyl)-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl]benzamide | US10183009, Example 3 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23N3O2 | ||
| Mol. Mass. | 349.4262 | ||
| SMILES | CN(C)C(=O)c1cccc(c1)-c1cn(CC=C(C)C)c(=O)c2[nH]ccc12 |(-2.52,-1.54,;-2.52,-3.08,;-3.85,-3.85,;-1.18,-3.85,;-1.18,-5.39,;.15,-3.08,;1.48,-3.85,;2.82,-3.08,;2.82,-1.54,;1.48,-.77,;.15,-1.54,;1.48,.77,;.15,1.54,;.15,3.08,;-1.18,3.85,;-2.52,3.08,;-3.85,3.85,;-3.85,5.39,;-5.19,3.08,;1.48,3.85,;1.48,5.39,;2.82,3.08,;4.28,3.56,;5.19,2.31,;4.28,1.06,;2.82,1.54,)| | ||
| Structure | 
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