| Reaction Details |
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 | Report a problem with these data |
| Target | Chromatin remodeling regulator CECR2 [424-538] |
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| Ligand | BDBM321476 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IC50 Measurements for Inhibitors Using TAF1-BD2 TR-FRET Binding Assay |
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| IC50 | 11.0±n/a nM |
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| Citation |  Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent US10183009 Publication Date 1/22/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Chromatin remodeling regulator CECR2 [424-538] |
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| Name: | Chromatin remodeling regulator CECR2 [424-538] |
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| Synonyms: | CECR2 | CECR2 (aa 424-538) | CECR2_HUMAN | Cat eye syndrome critical region protein 2 [424-538] | KIAA1740 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 13747.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BXF3[424-538] |
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| Residue: | 115 |
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| Sequence: | MREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISS
MEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKH
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| BDBM321476 |
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| n/a |
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| Name | BDBM321476 |
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| Synonyms: | 6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)phenyl]-2-methyl-1H-pyrrolo[2,3-c]pyridin-7-one | US10183009, Example 97 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24FN3O3 |
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| Mol. Mass. | 409.4534 |
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| SMILES | Cc1cc2c(cn(CCC=C)c(=O)c2[nH]1)-c1ccc(F)c(c1)C(=O)N1CCOCC1 |
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| Structure | 
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