Reaction Details |
| Report a problem with these data |
Target | Orexin/Hypocretin receptor type 1 |
---|
Ligand | BDBM315049 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Rat and Human Orexin 1 Receptor Radioligand Binding Studies |
---|
Ki | 4.00±n/a nM |
---|
Citation | Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US10183953 Publication Date 1/22/2019 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Orexin/Hypocretin receptor type 1 |
---|
Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
Type: | Protein |
Mol. Mass.: | 46817.55 |
Organism: | Rattus norvegicus (Rat) |
Description: | P56718 |
Residue: | 416 |
Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
|
|
|
BDBM315049 |
---|
n/a |
---|
Name | BDBM315049 |
Synonyms: | (2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-((5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone | US10183953, Example 230 | US9611277, Example 230 |
Type | Small organic molecule |
Emp. Form. | C22H19F3N6O |
Mol. Mass. | 440.4211 |
SMILES | FC(F)(F)c1cnc(NC2CC3CC2N(C3)C(=O)c2ccccc2-c2ncccn2)nc1 |TLB:16:14:9.10:12,THB:8:9:14.15:12| |
Structure |
|