Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM11451 |
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Substrate/Competitor | GSK-3 Peptide Substrate |
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Meas. Tech. | GSK-3 beta Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 11000±n/a nM |
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Citation | Richardson, CM; Williamson, DS; Parratt, MJ; Borgognoni, J; Cansfield, AD; Dokurno, P; Francis, GL; Howes, R; Moore, JD; Murray, JB; Robertson, A; Surgenor, AE; Torrance, CJ Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg Med Chem Lett16:1353-7 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3, beta | GSK3B_RAT | Glycogen Synthase Kinase-3, beta | Gsk3b |
Type: | Enzyme |
Mol. Mass.: | 46754.43 |
Organism: | Rattus norvegicus (rat) |
Description: | The rat GSK-3 beta cDNA was inserted into the baculovirus vector. The protein was purified from virus-infected sf9 insect cells |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDM
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST
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BDBM11451 |
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GSK-3 Peptide Substrate |
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Name: | GSK-3 Peptide Substrate |
Synonyms: | GS-1 Peptide | Phospho-GS2 Substrate Peptide |
Type: | Peptide |
Mol. Mass.: | 3045.17 |
Organism: | n/a |
Description: | n/a |
Residue: | 27 |
Sequence: | YRRAAVPPSPSLSRHSSPHQS(PO4)EDEEE
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