| Reaction Details |
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 | Report a problem with these data |
| Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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| Ligand | BDBM191570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human ENPP2 (hENPP2) Assay |
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| pH | 8.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 50±n/a nM |
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| Comments | extracted |
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| Citation |  Desroy, N; Heckmann, B; Brys, RC; Joncour, AM; Peixoto, C; Bock, XM Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders US Patent US9670204 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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| Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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| Synonyms: | ATX | Autotaxin | Autotaxin (ATX) | E-NPP 2 | ENPP2 | ENPP2_HUMAN | Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP2) | Extracellular lysophospholipase D | LysoPLD | PDNP2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 99007.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13822 |
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| Residue: | 863 |
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| Sequence: | MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI
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| BDBM191570 |
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| n/a |
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| Name | BDBM191570 |
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| Synonyms: | US10526329, Compound 12 | US11072611, Compound 12 | US11104665, WO2014/139882 Example 12 | US9670204, 12 2-((2-ethyl-8-fluoro-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)imidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile | WO2014139882, Compound 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30F2N8O2S |
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| Mol. Mass. | 592.663 |
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| SMILES | CCc1nc2c(F)cc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)N1CCN(CC(=O)N2CC(O)C2)CC1 |
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| Structure | 
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