| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Leukotriene A-4 hydrolase |
|---|
| Ligand | BDBM327173 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| IC50 | 0.490±n/a nM |
|---|
| Citation |  Bylock, LA Benzodioxane inhibitors of leukotriene production for combination therapy US Patent US9662339 Publication Date 5/30/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Leukotriene A-4 hydrolase |
|---|
| Name: | Leukotriene A-4 hydrolase |
|---|
| Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
|---|
| Type: | Hydrolase; metalloprotease |
|---|
| Mol. Mass.: | 69280.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant LTA4H. |
|---|
| Residue: | 611 |
|---|
| Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
|
|
|
|---|
| BDBM327173 |
|---|
| n/a |
|---|
| Name | BDBM327173 |
|---|
| Synonyms: | 1-{(1S,4S)-5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyridin-3-yl)- benzyl]-2,5-diaza- bicyclo[2.2.1]hept-2-yl}-2- methanesulfonyl-ethanone | US9662339, 256 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25N3O5S |
|---|
| Mol. Mass. | 443.516 |
|---|
| SMILES | CS(=O)(=O)CC(=O)N1C[C@@H]2C[C@H]1CN2Cc1ccc(cc1)[C@H]1COc2cccnc2O1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
