| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
|---|
| Ligand | BDBM328301 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme-Linked Immunosorbent Assay |
|---|
| EC50 | <500±n/a nM |
|---|
| Citation |  Irving, M; Shaw, S AMPK-activating heterocyclic compounds and methods for using the same US Patent US9663496 Publication Date 5/30/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
|---|
| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
|---|
| Synonyms: | AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62331.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P54646 |
|---|
| Residue: | 552 |
|---|
| Sequence: | MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
|
|
|
|---|
| BDBM328301 |
|---|
| n/a |
|---|
| Name | BDBM328301 |
|---|
| Synonyms: | N-(1-(4-methoxybenzyl) piperidin-4-yl)-6-(4-(4- (pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide | US10377742, Compound 439 | US9663496, Compound 439 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H43N5O4 |
|---|
| Mol. Mass. | 609.7577 |
|---|
| SMILES | COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
