| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase TTK |
|---|
| Ligand | BDBM329361 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Mps-1 Kinase Assay |
|---|
| IC50 | 15.0±n/a nM |
|---|
| Citation |  Schulze, V; Kosemund, D; Wengner, AM; Siemeister, G; Stöckigt, D; Brüning, M Substituted triazolopyridines and their use as TTK inhibitors US Patent US9663510 Publication Date 5/30/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase TTK |
|---|
| Name: | Dual specificity protein kinase TTK |
|---|
| Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 97086.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P33981 |
|---|
| Residue: | 857 |
|---|
| Sequence: | MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK
|
|
|
|---|
| BDBM329361 |
|---|
| n/a |
|---|
| Name | BDBM329361 |
|---|
| Synonyms: | US9663510, Example comparitive example 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H26FN5O4S |
|---|
| Mol. Mass. | 571.622 |
|---|
| SMILES | COc1cc(ccc1Nc1nc2ccc(cn2n1)-c1ccc(NC(=O)C2(CC2)c2ccc(F)cc2)cc1)S(C)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
