| Reaction Details |
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 | Report a problem with these data |
| Target | Apolipoprotein L1 |
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| Ligand | BDBM615180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Trypanosoma brucei Brucei Lysis Assay |
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| IC50 | 600±n/a nM |
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| Citation |  CAO, J; COME, JH; DAKIN, LA; DENIS, F; DORSCH, WA; FORTIER, A; HAMEL, M; KRUEGER, EB; LEDFORD, B; NANTHAKUMAR, SS; NICOLAS, O; SAYEGH, C; SENTER, TJ; WANG, T; BRODNEY, M; HU, K; ROSE, P; GAGNON, K; SHI, Y; SHRESTHA, M; MEDEK, A; WITKOS, F INHIBITORS OF APOL1 AND METHODS OF USING SAME US Patent US20230271945 Publication Date 8/31/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apolipoprotein L1 |
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| Name: | Apolipoprotein L1 |
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| Synonyms: | APOL | APOL1 | APOL1_HUMAN | Apo-L | ApoL-I | Apolipoprotein L | Apolipoprotein L-I | Apolipoprotein L1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43969.63 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_120089 |
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| Residue: | 398 |
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| Sequence: | MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTM
DPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLAR
QMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSG
SLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQA
HDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHAS
ASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLH
EGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL
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| BDBM615180 |
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| n/a |
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| Name | BDBM615180 |
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| Synonyms: | 3-(5,6-difluoro-7-methyl-2-phenyl-1H-indol-3-yl)-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide (99) | US20230271945, Compound 99 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21F2N3O3 |
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| Mol. Mass. | 413.4172 |
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| SMILES | Cc1c(F)c(F)cc2c(CCC(=O)N[C@H]3[C@H](O)CNC3=O)c([nH]c12)-c1ccccc1 |r| |
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| Structure | 
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