| Reaction Details |
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 | Report a problem with these data |
| Target | Apolipoprotein L1 |
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| Ligand | BDBM615182 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Acute APOL1 Thallium Assay |
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| IC50 | 600±n/a nM |
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| Citation |  CAO, J; COME, JH; DAKIN, LA; DENIS, F; DORSCH, WA; FORTIER, A; HAMEL, M; KRUEGER, EB; LEDFORD, B; NANTHAKUMAR, SS; NICOLAS, O; SAYEGH, C; SENTER, TJ; WANG, T; BRODNEY, M; HU, K; ROSE, P; GAGNON, K; SHI, Y; SHRESTHA, M; MEDEK, A; WITKOS, F INHIBITORS OF APOL1 AND METHODS OF USING SAME US Patent US20230271945 Publication Date 8/31/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apolipoprotein L1 |
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| Name: | Apolipoprotein L1 |
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| Synonyms: | APOL | APOL1 | APOL1_HUMAN | Apo-L | ApoL-I | Apolipoprotein L | Apolipoprotein L-I | Apolipoprotein L1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43969.63 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_120089 |
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| Residue: | 398 |
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| Sequence: | MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTM
DPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLAR
QMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSG
SLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQA
HDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHAS
ASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLH
EGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL
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| BDBM615182 |
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| n/a |
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| Name | BDBM615182 |
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| Synonyms: | 3-[7-fluoro-2-(4-fluorophenyl)-5-(trifluoromethyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide (101) | US20230271945, Compound 101 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18F5N3O3 |
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| Mol. Mass. | 467.3886 |
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| SMILES | O[C@@H]1CNC(=O)[C@H]1NC(=O)CCc1c([nH]c2c(F)cc(cc12)C(F)(F)F)-c1ccc(F)cc1 |r| |
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| Structure | 
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