Reaction Details |
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Target | Serine/threonine-protein kinase B-raf [V600E] |
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Ligand | BDBM333647 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Competition Binding Assay |
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Kd | >1000±n/a nM |
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Citation | Abraham, S; Bhagwat, SS; Campbell, BT; Chao, Q; Faraoni, R; Holladay, MW; Lai, AG; Rowbottom, MW; Setti, E; Sprankle, KG RAF kinase modulator compounds and methods of use thereof US Patent US9730937 Publication Date 8/15/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase B-raf [V600E] |
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Name: | Serine/threonine-protein kinase B-raf [V600E] |
Synonyms: | B-RAF V600E | B-Raf (V600E) | B-Raf Protein Kinase Mutant (V600E) | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF (V600E) | BRAF mutant V600E | BRAF1 | BRAF_HUMAN | P15056 | Protein mono-ADP-ribosyltransferase (PARP3) | RAF serine/threonine protein kinase (V600E) | RAFB1 | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf [V600E] | V-RAF murine sarcoma viral oncogene homologue B1 mutant (BRAF V600E) |
Type: | n/a |
Mol. Mass.: | 84474.98 |
Organism: | Homo sapiens (Human) |
Description: | P15056 V600E |
Residue: | 766 |
Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATE
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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BDBM333647 |
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n/a |
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Name | BDBM333647 |
Synonyms: | 1-[3-(1,3- difluoro-2- methylpropan- 2-yl)-1- phenyl-1H- pyrazol-5- yl]-3-[3-(6,7- dimethoxy- quinazolin- 4- ylthio)phenyl] urea | US9730937, Example 196 |
Type | Small organic molecule |
Emp. Form. | C30H28F2N6O3S |
Mol. Mass. | 590.644 |
SMILES | COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(nn4-c4ccccc4)C(C)(CF)CF)c3)c2cc1OC |
Structure |
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