Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM13671 |
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Substrate/Competitor | BDBM12500 |
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Meas. Tech. | Factor Xa Inhibition Assay |
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Ki | 153±n/a nM |
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Citation | Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Structural requirements for factor Xa inhibition by 3-oxybenzamides with neutral P1 substituents: combining X-ray crystallography, 3D-QSAR, and tailored scoring functions. J Med Chem48:3290-312 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM13671 |
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BDBM12500 |
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Name | BDBM13671 |
Synonyms: | (2S)-5-carbamimidamido-2-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}formamido)-N,N-diethylpentanamide | 3-Oxybenzamide 57 |
Type | Small organic molecule |
Emp. Form. | C26H35Cl2N5O4 |
Mol. Mass. | 552.493 |
SMILES | [#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-c1ccc(-[#8]-[#6])c(-[#8]-[#6]-[#6]-c2ccc(Cl)cc2Cl)c1 |r| |
Structure |
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