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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Phosphatidylinositol 3-kinase regulatory subunit beta | ||
| Ligand | BDBM338881 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 300±n/a nM | ||
| Citation |  Castro, AC; Evans, CA; Janardanannair, S; Lescarbeau, A; Liu, T; Tremblay, MR Heterocyclic compounds and uses thereof US Patent US9751888 Publication Date 9/5/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Phosphatidylinositol 3-kinase regulatory subunit beta | |||
| Name: | Phosphatidylinositol 3-kinase regulatory subunit beta | ||
| Synonyms: | P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 81542.75 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00459 | ||
| Residue: | 728 | ||
| Sequence: |
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| BDBM338881 | |||
| n/a | |||
| Name | BDBM338881 | ||
| Synonyms: | US9751888, Compound 72 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24ClN7O4S | ||
| Mol. Mass. | 529.999 | ||
| SMILES | C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(Cl)c2c(=O)n1C1CC(C1)NS(C)(=O)=O |r,wD:1.0,(-1.45,.19,;.06,.51,;.54,1.98,;-.49,3.12,;-2,2.8,;-.02,4.59,;-.92,5.83,;-2.46,5.83,;-.02,7.08,;1.45,6.6,;2.78,7.37,;4.11,6.6,;4.11,5.06,;2.78,4.29,;1.45,5.06,;1.09,-.63,;2.6,-.31,;3.63,-1.46,;5.13,-1.14,;6.16,-2.28,;5.69,-3.75,;4.18,-4.07,;3.71,-5.53,;3.15,-2.92,;1.64,-3.24,;1.17,-4.71,;.61,-2.1,;-.89,-2.42,;-1.73,-3.71,;-3.02,-2.87,;-2.18,-1.58,;-4.53,-3.19,;-5,-4.66,;-5.48,-6.12,;-6.47,-4.18,;-3.54,-5.13,)| | ||
| Structure | 
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