| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
|---|
| Ligand | BDBM14060 |
|---|
| Substrate/Competitor | BDBM13015 |
|---|
| Meas. Tech. | Radiochemical Assay for PNMT Activity |
|---|
| pH | 8±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| Ki | 370±40 nM |
|---|
| Citation |  McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J Med Chem47:37-44 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Phenylethanolamine N-methyltransferase |
|---|
| Name: | Phenylethanolamine N-methyltransferase |
|---|
| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 30916.97 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | n/a |
|---|
| Residue: | 283 |
|---|
| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
|
|
|
|---|
| BDBM14060 |
|---|
| BDBM13015 |
|---|
| Name | BDBM14060 |
|---|
| Synonyms: | 7-Iodo-1,2,3,4-tetrahydroisoquinoline | CHEMBL26828 | tetrahydroisoquinoline (THIQ) deriv. 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H10IN |
|---|
| Mol. Mass. | 259.0869 |
|---|
| SMILES | Ic1ccc2CCNCc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
