| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-2A adrenergic receptor [16-465] |
|---|
| Ligand | BDBM13017 |
|---|
| Substrate/Competitor | BDBM14062 |
|---|
| Meas. Tech. | alpha-Adrenoceptor Radioligand Binding Assay |
|---|
| pH | 7.7±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | 100000±20000 nM |
|---|
| Citation |  McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J Med Chem47:37-44 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Alpha-2A adrenergic receptor [16-465] |
|---|
| Name: | Alpha-2A adrenergic receptor [16-465] |
|---|
| Synonyms: | ADA2A_RAT | Adra2a | Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A |
|---|
| Type: | G-protein coupled receptor |
|---|
| Mol. Mass.: | 48961.69 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P22909[16-465] |
|---|
| Residue: | 450 |
|---|
| Sequence: | MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGG
QQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACS
APPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSE
HAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
|
|
|
|---|
| BDBM13017 |
|---|
| BDBM14062 |
|---|
| Name | BDBM13017 |
|---|
| Synonyms: | 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHEMBL26717 | SKF 29661 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H12N2O2S |
|---|
| Mol. Mass. | 212.269 |
|---|
| SMILES | NS(=O)(=O)c1ccc2CCNCc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
