Reaction Details |
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Target | Beta-secretase 1 |
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Ligand | BDBM204935 |
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Substrate/Competitor | n/a |
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Meas. Tech. | BACE1 Inhibiting Activity |
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pH | 5±n/a |
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Temperature | 303.15±n/a K |
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IC50 | 153±0.0 nM |
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Comments | extracted |
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Citation | Kusakabe, K; Yoshida, S; Nakahara, K; Hasegawa, T; Tadano, G; Fuchino, K Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity US Patent US9540359 Publication Date 1/10/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 1 |
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Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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BDBM204935 |
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n/a |
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Name | BDBM204935 |
Synonyms: | I-13 |
Type | Small organic molecule |
Emp. Form. | C20H17F3N4O2 |
Mol. Mass. | 402.3698 |
SMILES | NC1=CC(CCCO1)(C(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F |t:1| |
Structure |
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