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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Malignant T-cell-amplified sequence 1 | ||
| Ligand | BDBM345272 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Assay 4: MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells | ||
| IC50 | 45000±n/a nM | ||
| Citation |  Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Malignant T-cell-amplified sequence 1 | |||
| Name: | Malignant T-cell-amplified sequence 1 | ||
| Synonyms: | MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 20563.62 | ||
| Organism: | Homo sapiens (human) | ||
| Description: | n/a | ||
| Residue: | 181 | ||
| Sequence: |
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| BDBM345272 | |||
| n/a | |||
| Name | BDBM345272 | ||
| Synonyms: | 2-[[1-[(2-Chlorophenyl)methyl]-5-thiazol- 2-yl-pyrazol-3-yl]methoxy]-2-methyl- propanoic acid 1H NMR (CDCl3, 400 MHz) $#948; 1.38 (m, 6H), 4.48 (s, 2H), 5.61 (s, 2H), 6.55-6.65 (m, 1H), 7.03 (s, 1H), 7.09-7.16 (m, 1H), 7.17-7.23 (m, 1H), 7.27-7.33 (d, 1H), 7.34- 7.42 (m, 1H), 7.88-7.96 (d, 1H). | US10202350, Example 18 | US10214492, Example 18 | US11292767, Example 18 | US11724989, Example 18 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H18ClN3O3S | ||
| Mol. Mass. | 391.872 | ||
| SMILES | CC(C)(OCc1cc(-c2nccs2)n(Cc2ccccc2Cl)n1)C(O)=O | ||
| Structure | 
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