Reaction Details | |||
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Target | Malignant T-cell-amplified sequence 1 | ||
Ligand | BDBM345281 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Assay 4: MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells | ||
IC50 | 302±n/a nM | ||
Citation | Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Malignant T-cell-amplified sequence 1 | |||
Name: | Malignant T-cell-amplified sequence 1 | ||
Synonyms: | MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 20563.62 | ||
Organism: | Homo sapiens (human) | ||
Description: | n/a | ||
Residue: | 181 | ||
Sequence: |
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BDBM345281 | |||
n/a | |||
Name | BDBM345281 | ||
Synonyms: | 2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphenyl)pyrazol-3-yl]methoxy]-2- methyl-propanoic acid. 1HNMR (CDCl3): $#948; 0.95 (s, 3H)(, 0.96 (s, 3H), 1.56 (s, 6H), 1.97-2.03 (m, 1H), 3.49 (d, 2H), 4.63 (s, 2H), 5.43 (s, 2H), 6.41 (s, 1H), 6.73-6.80 (m, 2H), 6.84- 6.92 (m, 2H), 7.19-7.28 (m, 3H), 7.33- 7.35 (m, 1H). | US10202350, Example 27 | US10214492, Example 27 | US11292767, Example 27 | US11724989, Example 27 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H29ClN2O4 | ||
Mol. Mass. | 456.962 | ||
SMILES | CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl | ||
Structure |