Reaction Details |
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Target | Malignant T-cell-amplified sequence 1 |
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Ligand | BDBM345302 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Assay 4: MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells |
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IC50 | 55000±n/a nM |
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Citation | Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Malignant T-cell-amplified sequence 1 |
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Name: | Malignant T-cell-amplified sequence 1 |
Synonyms: | MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 20563.62 |
Organism: | Homo sapiens (human) |
Description: | n/a |
Residue: | 181 |
Sequence: | MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIE
ILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPG
AKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTY
K
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BDBM345302 |
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n/a |
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Name | BDBM345302 |
Synonyms: | 2-([1-[(o-Chlorophenyl)methyl]-5-(m- cyanophenyl)-1H-pyrazol-3-yl]methoxy)- 2-methylpropionic acid 1HNMR (CDCl3): $#948; 1.56 (s, 6H), 4.62 (s, 2H), 5.39 (s, 2H), 6.46 (s, 1H), 6.82-6.84 (m, 1H), 7.18-7.24 (m, 2H), 7.33-7.35 (m 1H), 7.46-7.55 (m, 3H), 7.65-7.68 (m, 1H). | US10202350, Example 48 | US10214492, Example 48 | US11292767, Example 48 | US11724989, Example 48 |
Type | Small organic molecule |
Emp. Form. | C22H20ClN3O3 |
Mol. Mass. | 409.866 |
SMILES | CC(C)(OCc1cc(-c2cccc(c2)C#N)n(Cc2ccccc2Cl)n1)C(O)=O |
Structure |
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