| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 2B |
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| Ligand | BDBM345415 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | KDM2B TR-FRET Assay |
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| IC50 | 0.112±n/a nM |
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| Citation |  Albrecht, BK; Cote, A; Gehling, V; Hsiao-Wei Tsui, V; Kiefer, JR; Liang, J; Magnuson, S; Nasveschuk, CG; Romero, FA; Taylor, AM Therapeutic compounds and uses thereof US Patent US10202354 Publication Date 2/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 2B |
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| Name: | Lysine-specific demethylase 2B |
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| Synonyms: | AA 1-650 | CXXC2 | FBL10 | FBXL10 | Homo sapiens lysine demethylase 2B (KDM2B) | JHDM1B | KDM2B | KDM2B_HUMAN | Lysine-specific demethylase 2B | Lysine-specific demethylase 2B (KDM2B) | NDY1 | NM_032590 | PCCX2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 152658.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8NHM5 |
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| Residue: | 1336 |
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| Sequence: | MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVE
EIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPD
PDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTD
FHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIEL
KQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQ
EEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEES
VKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAAN
RTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTA
VCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECP
KCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE
HSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSS
LSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEA
PPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQR
TENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPP
RVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQ
DLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQ
LSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTD
NRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT
AVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSV
SVQFGQVEEKLLQKLS
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| BDBM345415 |
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| n/a |
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| Name | BDBM345415 |
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| Synonyms: | 6-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimidazol-1-yl]sulfonyl]-2-methyl-1,3-benzothiazole | US10202354, Example 80 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N5O2S2 |
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| Mol. Mass. | 419.564 |
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| SMILES | Cc1nc2ccc(cc2s1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:18| |
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| Structure | 
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