| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 2 |
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| Ligand | BDBM329881 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Assay |
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| IC50 | 550±n/a nM |
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| Citation |  Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent US9796725 Publication Date 10/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| SUMO-activating enzyme subunit 2 |
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| Name: | SUMO-activating enzyme subunit 2 |
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| Synonyms: | 6.3.2.- | Anthracycline-associated resistance ARX | SAE2 | SAE2_HUMAN | SUMO-activating enzyme subunit 2 | SUMO-activating enzyme subunit 2 (SAE2) | UBA2 | UBLE1B | Ubiquitin-like 1-activating enzyme E1B | Ubiquitin-like modifier-activating enzyme 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 71206.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UBT2 |
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| Residue: | 640 |
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| Sequence: | MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQ
FLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRA
ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS
EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRIST
KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ
NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN
LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK
QPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDV
QIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK
DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN
ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
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| BDBM329881 |
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| n/a |
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| Name | BDBM329881 |
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| Synonyms: | (rac)-{(1R,2R,3S,4R)-2,3-dihydroxy-4-[(6-methyl-2-phenylpyrazolo[1,5-a]pyrimidin- | US10202389, Compound I-089 | US9663525, Compound I-089 | US9796725, Compound I-089 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N5O5S |
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| Mol. Mass. | 433.481 |
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| SMILES | Cc1cnc2cc(nn2c1N[C@@H]1C[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O)-c1ccccc1 |r| |
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| Structure | 
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