Reaction Details | |||
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Target | Monocarboxylate transporter 4 | ||
Ligand | BDBM345281 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells | ||
IC50 | 1.000±n/a nM | ||
Citation | Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent US10214492 Publication Date 2/26/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Monocarboxylate transporter 4 | |||
Name: | Monocarboxylate transporter 4 | ||
Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 49474.36 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_104604 | ||
Residue: | 465 | ||
Sequence: |
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BDBM345281 | |||
n/a | |||
Name | BDBM345281 | ||
Synonyms: | 2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphenyl)pyrazol-3-yl]methoxy]-2- methyl-propanoic acid. 1HNMR (CDCl3): $#948; 0.95 (s, 3H)(, 0.96 (s, 3H), 1.56 (s, 6H), 1.97-2.03 (m, 1H), 3.49 (d, 2H), 4.63 (s, 2H), 5.43 (s, 2H), 6.41 (s, 1H), 6.73-6.80 (m, 2H), 6.84- 6.92 (m, 2H), 7.19-7.28 (m, 3H), 7.33- 7.35 (m, 1H). | US10202350, Example 27 | US10214492, Example 27 | US11292767, Example 27 | US11724989, Example 27 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H29ClN2O4 | ||
Mol. Mass. | 456.962 | ||
SMILES | CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl | ||
Structure |