Reaction Details | |||
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Target | Monocarboxylate transporter 4 | ||
Ligand | BDBM345296 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells | ||
IC50 | 2.60±n/a nM | ||
Citation | Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent US10214492 Publication Date 2/26/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Monocarboxylate transporter 4 | |||
Name: | Monocarboxylate transporter 4 | ||
Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 49474.36 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_104604 | ||
Residue: | 465 | ||
Sequence: |
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BDBM345296 | |||
n/a | |||
Name | BDBM345296 | ||
Synonyms: | 2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclobutylmethoxy)phenyl]pyrazol-3- yl]methoxy]-2-methyl-propanoic acid. 1HNMR (CDCl3): $#948; 1.55 (s, 6H), 1.75- 1.82 (m, 2H), 1.85-1.98 (m, 2H), 2.06- 2.14 (m, 2H), 2.64-2.70 (m, 1H), 3.71 (d, 2H), 4.63 (s, 2H), 5.43 (s, 2H), 6.42 (s, 1H), 6.75-6.92 (m, 4H), 7.20-7.36 (m, 4). | US10202350, Example 42 | US10214492, Example 42 | US11292767, Example 42 | US11724989, Example 42 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H29ClN2O4 | ||
Mol. Mass. | 468.972 | ||
SMILES | CC(C)(OCc1cc(-c2cccc(OCC3CCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O | ||
Structure |