Reaction Details | |||
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Target | Monocarboxylate transporter 4 | ||
Ligand | BDBM345315 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells | ||
IC50 | 3.10±n/a nM | ||
Citation | Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent US10214492 Publication Date 2/26/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Monocarboxylate transporter 4 | |||
Name: | Monocarboxylate transporter 4 | ||
Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 49474.36 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_104604 | ||
Residue: | 465 | ||
Sequence: |
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BDBM345315 | |||
n/a | |||
Name | BDBM345315 | ||
Synonyms: | 2-([1-[(2-methoxyphenyl)methyl]-5-[3-(2- methylpropoxy)phenyl]-1H-pyrazol-3- yl]methoxy)-2-methylpropanoic acid LC-MS (ES, m/z): 453 1H-NMR (400 MHz, MeOD) $#948; 0.97 (6 H, d), 1.53 (6 H, s), 1.97 (1 H, dp), 3.48 (2 H, d), 3.78 (3 H, s), 4.58 (2 H, s), 5.31 (2 H, s), 6.52 (1 H, s), 6.67-6.74 (1 H, m), 6.76- 6.82 (1 H, m), 6.85-7.00 (4 H, m), 7.22- 7.33 (2 H, m). | US10202350, Example 61 | US10214492, Example 61 | US11292767, Example 61 | US11724989, Example 61 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H32N2O5 | ||
Mol. Mass. | 452.5427 | ||
SMILES | COc1ccccc1Cn1nc(COC(C)(C)C(O)=O)cc1-c1cccc(OCC(C)C)c1 | ||
Structure |