| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monocarboxylate transporter 4 |
|---|
| Ligand | BDBM356909 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells |
|---|
| IC50 | 0.830±n/a nM |
|---|
| Citation |  Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent US10214492 Publication Date 2/26/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monocarboxylate transporter 4 |
|---|
| Name: | Monocarboxylate transporter 4 |
|---|
| Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49474.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_104604 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
|
|
|
|---|
| BDBM356909 |
|---|
| n/a |
|---|
| Name | BDBM356909 |
|---|
| Synonyms: | US10214492, Example 260 | US11292767, Example 260 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H31N3O4 |
|---|
| Mol. Mass. | 461.5527 |
|---|
| SMILES | CC(C)(OCc1cc(-c2cccc(OC3CCC3)c2)n(n1)-c1ccccc1N1CCC1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
