| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM360586 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity Assay |
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| IC50 | 197±n/a nM |
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| Citation |  Imbriglio, J; London, C; Lu, Z; Tata, J; Xiong, Y; You, M; Youm, H Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US9828369 Publication Date 11/28/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM360586 |
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| n/a |
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| Name | BDBM360586 |
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| Synonyms: | 2-(6-methoxynaphthalen-2-yl)-N-((5- (3-methoxyphenyl)isoquinolin-8- yl)methyl)propanamide | US9828369, Example 143 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H28N2O3 |
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| Mol. Mass. | 476.5656 |
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| SMILES | COc1cccc(c1)-c1ccc(CNC(=O)C(C)c2ccc3cc(OC)ccc3c2)c2cnccc12 |
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| Structure | 
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