Reaction Details |
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Target | Cytosolic arginine sensor for mTORC1 subunit 1 |
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Ligand | BDBM315544 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | <10±n/a nM |
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Citation | Ren, P; Liu, Y; Li, L; Chan, K; Wilson, TE Kinase inhibitors and methods of use US Patent US9828378 Publication Date 11/28/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Cytosolic arginine sensor for mTORC1 subunit 1 |
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Name: | Cytosolic arginine sensor for mTORC1 subunit 1 |
Synonyms: | CAST1_HUMAN | CASTOR1 | Cellular arginine sensor for mTORC1 protein 1 | GATS-like protein 3 | GATSL3 | mTORC1 protein 1 |
Type: | Protein |
Mol. Mass.: | 36264.36 |
Organism: | Homo sapiens (Human) |
Description: | Q8WTX7 |
Residue: | 329 |
Sequence: | MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGF
KELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQT
DFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSP
QNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIV
MDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYIST
FNFDHALVPEDGIGSVIEVLQRRQEGLAS
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BDBM315544 |
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n/a |
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Name | BDBM315544 |
Synonyms: | US10172858, Table 2.39 | US9828378, # 39 |
Type | Small organic molecule |
Emp. Form. | C16H15ClN6O |
Mol. Mass. | 342.783 |
SMILES | CC(C)n1nc(-c2cc3c(Cl)ccc(O)c3[nH]2)c2c(N)ncnc12 |
Structure |
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