| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM362864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF-Based Assay |
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| IC50 | 61.0±n/a nM |
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| Citation |  Bennett, DJ; Cai, J; Carswell, E; Cooke, A; Hoyt, SB; London, C; MacLean, J; Park, MK; Ratcliffe, P; Xiong, Y; Samanta, SK; Kulkarni, BA Pyrazolopyridyl compounds as aldosterone synthase inhibitors US Patent US9844553 Publication Date 12/19/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 57582.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19099 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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| BDBM362864 |
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| n/a |
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| Name | BDBM362864 |
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| Synonyms: | 2-(5-methylpyridin-3-yl)-5-oxo-4,5,6,7- tetrahydropyrazolo[1,5-a]pyrimidine-3- carbonitrile | US9844553, 25 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11N5O |
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| Mol. Mass. | 253.2593 |
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| SMILES | Cc1cncc(c1)-c1nn2CCC(=O)Nc2c1C#N |
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| Structure | 
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