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TargetCytochrome P450 11B2, mitochondrial
LigandBDBM362864
Substrate/Competitorn/a
Meas. Tech.HTRF-Based Assay
IC50 61.0±n/a nM
Citation Bennett, DJCai, JCarswell, ECooke, AHoyt, SBLondon, CMacLean, JPark, MKRatcliffe, PXiong, YSamanta, SKKulkarni, BA Pyrazolopyridyl compounds as aldosterone synthase inhibitors US Patent US9844553 Publication Date 12/19/2017
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 11B2, mitochondrial
Name:Cytochrome P450 11B2, mitochondrial
Synonyms:Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:Protein
Mol. Mass.:57582.15
Organism:Homo sapiens (Human)
Description:P19099
Residue:503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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BDBM362864
n/a
NameBDBM362864
Synonyms:2-(5-methylpyridin-3-yl)-5-oxo-4,5,6,7- tetrahydropyrazolo[1,5-a]pyrimidine-3- carbonitrile | US9844553, 25
TypeSmall organic molecule
Emp. Form.C13H11N5O
Mol. Mass.253.2593
SMILESCc1cncc(c1)-c1nn2CCC(=O)Nc2c1C#N
Structure
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