Reaction Details |
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Target | Cathepsin S |
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Ligand | BDBM19860 |
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Substrate/Competitor | BDBM19490 |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | 33000±n/a nM |
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EC50 | >10000±n/a nM |
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Citation | Falgueyret, JP; Desmarais, S; Oballa, R; Black, WC; Cromlish, W; Khougaz, K; Lamontagne, S; Massé, F; Riendeau, D; Toulmond, S; Percival, MD Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J Med Chem48:7535-43 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cathepsin S |
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Name: | Cathepsin S |
Synonyms: | CATS_MOUSE | Cats | Ctss |
Type: | Enzyme |
Mol. Mass.: | 38476.67 |
Organism: | Mus musculus (Mouse) |
Description: | O70370 |
Residue: | 340 |
Sequence: | MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIW
EKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSN
RTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSN
EEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLP
FGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGK
DYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
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BDBM19860 |
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BDBM19490 |
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Name | BDBM19860 |
Synonyms: | 4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]-N-{1-[(2,2,2-trifluoroethyl)carbamoyl]cyclohexyl}benzamide | piperazine-containing compound, 2 |
Type | Small organic molecule |
Emp. Form. | C24H30F3N5O2S |
Mol. Mass. | 509.588 |
SMILES | CN1CCN(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC(F)(F)F |
Structure |
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