| Reaction Details |
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 | Report a problem with these data |
| Target | Programmed cell death 1 ligand 1 |
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| Ligand | BDBM363433 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogenous Time-Resolved Fluorescence (HTRF) Binding Assay |
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| IC50 | 5.3±n/a nM |
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| Citation |  Chupak, LS; Ding, M; Martin, SW; Zheng, X; Hewawasam, P; Connolly, TP; Xu, N; Yeung, K; Zhu, J; Langley, DR; Scola, PM Compounds useful as immunomodulators US Patent US9850225 Publication Date 12/26/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Programmed cell death 1 ligand 1 |
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| Name: | Programmed cell death 1 ligand 1 |
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| Synonyms: | B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33278.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109807 |
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| Residue: | 290 |
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| Sequence: | MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
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| BDBM363433 |
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| n/a |
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| Name | BDBM363433 |
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| Synonyms: | (2S,5S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-5-hydroxypiperidine-2-carboxylic acid | US9850225, Example 2007 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H34ClN3O7 |
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| Mol. Mass. | 656.124 |
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| SMILES | Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN3C[C@@H](O)CC[C@H]3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1 |r| |
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| Structure | 
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