| Reaction Details |
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 | Report a problem with these data |
| Target | Ghrelin O-acyltransferase |
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| Ligand | BDBM367612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human GOAT Enzymatic Assay |
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| IC50 | 96.4±28.3 nM |
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| Citation |  Galka, CS; Hembre, EJ; Honigschmidt, NA; Martinez-Grau, MA; Plaza, GR; Rubio, A; Keding, SJ; Smith, DL Ghrelin 0-acyl transferase inhibitors US Patent US10227310 Publication Date 3/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ghrelin O-acyltransferase |
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| Name: | Ghrelin O-acyltransferase |
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| Synonyms: | GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 49733.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96T53 |
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| Residue: | 435 |
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| Sequence: | MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYA
VLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITL
SSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSL
CSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFEC
IYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRIS
VFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYL
IHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVY
CILLLLLAKRKHKCN
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| BDBM367612 |
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| n/a |
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| Name | BDBM367612 |
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| Synonyms: | N-[(1S)-2-[4-[2-(4-Amino-6-chloro-2-methyl-pyrimidin-5-yl)ethyl]-1-piperidyl]-1-methyl-2-oxo-ethyl]-2-methyl-thiazole-5-carboxamide | US10227310, Example 42 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H27ClN6O2S |
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| Mol. Mass. | 450.985 |
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| SMILES | C[C@H](NC(=O)c1cnc(C)s1)C(=O)N1CCC(CCc2c(N)nc(C)nc2Cl)CC1 |r| |
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| Structure | 
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