Reaction Details |
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Target | Ceramide glucosyltransferase |
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Ligand | BDBM367640 |
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Substrate/Competitor | n/a |
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Meas. Tech. | GCS Enzymatic Assay |
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IC50 | 5.5±n/a nM |
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Citation | Wang, B Glucosylceramide synthase inhibitors for the treatment of diseases US Patent US10227312 Publication Date 3/12/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Ceramide glucosyltransferase |
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Name: | Ceramide glucosyltransferase |
Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
Type: | PROTEIN |
Mol. Mass.: | 44859.25 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1435474 |
Residue: | 394 |
Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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BDBM367640 |
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n/a |
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Name | BDBM367640 |
Synonyms: | N-((1R,2R)-1-(4-cyclopropoxyphenyl)- 1-hydroxy-3-(pyrrolidin-1-yl)propan-2- yl)-1H-naphtho[2,1-d][1,2]oxazine-4- carboxamide | US10227312, Example 25 | US10759769, Example 25 |
Type | Small organic molecule |
Emp. Form. | C29H31N3O4 |
Mol. Mass. | 485.5741 |
SMILES | O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1=NOCc2c1ccc1ccccc21)c1ccc(OC2CC2)cc1 |r,t:13| |
Structure |
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