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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [342-460] | ||
| Ligand | BDBM362664 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | BRD4 AlphaScreen Assay | ||
| IC50 | <25±n/a nM | ||
| Citation |  Combs, AP; Sparks, RB Tricyclic heterocycles as bet protein inhibitors US Patent US10227359 Publication Date 3/12/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [342-460] | |||
| Name: | Bromodomain-containing protein 4 [342-460] | ||
| Synonyms: | BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 13783.81 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | a.a. 342-460 (BRD4-BD2) | ||
| Residue: | 119 | ||
| Sequence: |
| ||
| BDBM362664 | |||
| n/a | |||
| Name | BDBM362664 | ||
| Synonyms: | N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]piperidin-4-yl}-N- methylcyclopropanecarboxamide | US10227359, Example 19 | US9834565, Example 19 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H32N6O3 | ||
| Mol. Mass. | 512.6028 | ||
| SMILES | CN(C1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccn4)n1c23)C(=O)C1CC1 |(-1.35,6.78,;-2.12,5.44,;-1.35,4.11,;-2.12,2.78,;-1.35,1.44,;.19,1.44,;.96,2.78,;.19,4.11,;.96,.11,;2.5,.11,;3.06,-1.33,;4.39,-2.1,;4.39,-3.64,;3.06,-4.41,;3.06,-5.95,;1.81,-6.85,;.35,-6.38,;2.29,-8.32,;3.83,-8.32,;4.3,-6.85,;5.77,-6.38,;1.72,-3.64,;.39,-4.41,;-.94,-3.64,;-.94,-2.1,;-2.28,-1.33,;-3.61,-2.1,;-4.94,-1.33,;-4.94,.21,;-3.61,.98,;-2.28,.21,;.39,-1.33,;1.72,-2.1,;-3.66,5.44,;-4.43,4.11,;-4.43,6.78,;-5.77,7.55,;-4.43,8.32,)| | ||
| Structure | 
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